Percutaneous absorption of progesterone in postmenopausal women treated with transdermal estrogen

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Percutaneous absorption of progesterone in postmenopausal women treated with transdermal estrogen.

OBJECTIVE The objective of this study was to evaluate the serum levels of progesterone resulting from the application of a progesterone cream to the skin. STUDY DESIGN Six postmenopausal women were evaluated at a university clinic over a 4-week period. RESULTS Transdermal estradiol 0.05 mg was applied 2 days before the first application of progesterone (30 mg/d) and was continued throughout...

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The effects of transdermal estrogen delivery on bone mineral density in postmenopausal women: A meta-analysis

Background: Due to its minimal systematic adverse effects, transdermal estrogen is widely used for the prevention of osteoporosis in postmenopausal women.The present meta-analysis aimed to clarify the effects of transdermal estrogen on bone mineral density (BMD) of postmenopausal women.Methods: Studies were identified by searching electronic databases including Cochrane Library, MEDLINE, Embase...

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The effects of transdermal estrogen delivery on bone mineral density in postmenopausal women: A meta-analysis

Background: Due to its minimal systematic adverse effects, transdermal estrogen is widely used for the prevention of osteoporosis in postmenopausal women.The present meta-analysis aimed to clarify the effects of transdermal estrogen on bone mineral density (BMD) of postmenopausal women.Methods: Studies were identified by searching electronic databases including Cochrane Library, MEDLINE, Embase...

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Transdermal progesterone creams for postmenopausal women: more hype than hope?

Various claims have been made about the benefits of transdermal progesterone creams for relieving symptoms of menopause. Peer-reviewed articles have reported that the creams can raise plasma progesterone levels slightly, but have no effect on vasomotor, psychosexual or mood symptoms, bone metabolism or plasma lipid levels. Currently available progesterone creams can not be recommended for treat...

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Transdermal estrogen replacement therapy decreases sympathetic activity in postmenopausal women.

BACKGROUND Menopause heralds a dramatic increase in incident hypertension, suggesting a protective effect of estrogen on blood pressure (BP). In female rats, estrogen has been shown to decrease sympathetic nerve discharge (SND) and BP. SND, however, has not been recorded during estrogen replacement therapy (ERT) in humans. Methods and Results-In 12 normotensive postmenopausal women, we conducte...

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ژورنال

عنوان ژورنال: American Journal of Obstetrics and Gynecology

سال: 1999

ISSN: 0002-9378

DOI: 10.1016/s0002-9378(99)70046-3